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para ‐Selective C−H Borylation of (Hetero)Arenes by Cooperative Iridium/Aluminum Catalysis
Author(s) -
Yang Lichen,
Semba Kazuhiko,
Nakao Yoshiaki
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201701238
Subject(s) - borylation , iridium , chemistry , regioselectivity , catalysis , lewis acids and bases , combinatorial chemistry , organic chemistry , aryl , alkyl
para ‐Selective C−H borylation of benzamides and pyridines has been achieved by cooperative iridium/aluminum catalysis. A combination of iridium catalysts commonly employed for arene C−H borylation and bulky aluminum‐based Lewis acid catalysts provides an unprecedented strategy for controlling the regioselectivity of C−H borylation to give variously substituted (hetero)arylboronates, which are versatile synthetic intermediates for complex multi‐substituted aromatic compounds.