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Asymmetric Copper‐Catalyzed Carbomagnesiation of Cyclopropenes
Author(s) -
Dian Longyang,
Müller Daniel S.,
Marek Ilan
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201701094
Subject(s) - cyclopropene , enantioselective synthesis , electrophile , chemistry , catalysis , copper , combinatorial chemistry , organic chemistry
The highly diastereo‐ and enantioselective formation of polysubstituted cyclopropanes was easily achieved through the asymmetric copper‐catalyzed carbomagnesiation reaction of nonfunctionalized cyclopropene derivatives. The carbometalated species generated in situ readily undergo C−C and C−X bond‐forming reactions with various electrophiles with complete retention of configuration.