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Four‐Component Synthesis of Phosphonium Salts: Application Toward an Alternative Approach to Cross‐Coupling for the Synthesis of Bis‐Heteroarenes
Author(s) -
Chen YiRu,
Reddy Ganapuram Madhusudhan,
Hong ShaoHao,
Wang YingZheng,
Yu JhenKuei,
Lin Wenwei
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201700945
Subject(s) - phosphonium , chemistry , aldehyde , nucleophile , phosphine , aryl , heteroatom , component (thermodynamics) , combinatorial chemistry , coupling reaction , organic chemistry , ring (chemistry) , alkyl , catalysis , physics , thermodynamics
A series of stable phosphonium salts have been synthesized via a novel four‐component reaction of an arene nucleophile, 2‐heteroatom substituted aryl aldehyde, and phosphine in presence of an acid. The phosphonium salts thus obtained were utilized for the synthesis of a variety of bis‐heteroarenes, providing an efficient alternative method to the classical cross‐coupling strategies.