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Catalytic Enantioselective Synthesis of 2,5‐Dihydrooxepines
Author(s) -
Shim Su Yong,
Cho Soo Min,
Venkateswarlu Anipireddy,
Ryu Do Hyun
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201700890
Subject(s) - enantioselective synthesis , cyclopropanation , catalysis , chemistry , tandem , combinatorial chemistry , organic chemistry , materials science , composite material
A Michael addition initiated cyclopropanation/retro‐Claisen rearrangement tandem reaction was developed for the enantioselective synthesis of highly functionalized 2,5‐dihydrooxepines. In the presence of a chiral oxazaborolidinium ion (COBI) catalyst, the reaction proceeds to give good yields and high enantioselectivity.