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One‐Pot Multicomponent Synthesis of β‐Amino Amides
Author(s) -
Huang Bo,
Zeng Linwei,
Shen Yangyong,
Cui Sunliang
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201700840
Subject(s) - chemistry , combinatorial chemistry , amino acid , isotopic labeling , molecule , reaction conditions , chemical synthesis , scalability , organic chemistry , catalysis , computer science , biochemistry , database , in vitro
Multicomponent reactions are excellent tools for rapid generation of small molecules with broad chemical diversity and molecular complexity. Herein, a novel one‐pot multicomponent synthesis of β‐amino amides from aldehydes, anilines, carboxylic acids and ynamides has been successfully developed. This process is practical and efficient to unravel synthetic utility and scalability. Moreover, an isotope labeling reaction was conducted to elucidate a plausible reaction mechanism.