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Manganese‐Catalyzed N‐Formylation of Amines by Methanol Liberating H 2 : A Catalytic and Mechanistic Study
Author(s) -
Chakraborty Subrata,
Gellrich Urs,
DiskinPosner Yael,
Leitus Gregory,
Avram Liat,
Milstein David
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201700681
Subject(s) - formamides , formylation , catalysis , chemistry , manganese , pincer movement , methanol , base (topology) , formamide , metal , combinatorial chemistry , medicinal chemistry , organic chemistry , mathematical analysis , mathematics
The first example of a base metal (manganese) catalyzed acceptorless dehydrogenative coupling of methanol and amines to form formamides is reported herein. The novel pincer complex ( i Pr‐PN H P)Mn(H)(CO) 2 catalyzes the reaction under mild conditions in the absence of any additives, bases, or hydrogen acceptors. Mechanistic insight based on the observation of an intermediate and DFT calculations is also provided.