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Yttrium‐Catalyzed Intramolecular Hydroalkoxylation/Claisen Rearrangement Sequence: Efficient Synthesis of Medium‐Sized Lactams
Author(s) -
Zhou Bo,
Li Long,
Zhu XinQi,
Yan JuanZhu,
Guo YiLin,
Ye LongWu
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201700596
Subject(s) - intramolecular force , claisen rearrangement , yttrium , catalysis , chemistry , combinatorial chemistry , sequence (biology) , cascade , stereochemistry , organic chemistry , oxide , biochemistry , chromatography
An efficient yttrium‐catalyzed intramolecular hydroalkoxylation/Claisen rearrangement sequence has been achieved, thus enabling facile access to a diverse array of valuable medium‐sized lactams. Furthermore, a mechanistic rationale for this novel cascade reaction is well supported by a variety of control experiments.