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Auto‐Tandem Catalysis with Frustrated Lewis Pairs for Reductive Etherification of Aldehydes and Ketones
Author(s) -
Bakos Mária,
Gyömöre Ádám,
Domján Attila,
Soós Tibor
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201700231
Subject(s) - frustrated lewis pair , catalysis , chemistry , reductive elimination , tandem , lewis acids and bases , brønsted–lowry acid–base theory , combinatorial chemistry , organic chemistry , materials science , composite material
Herein we report that a single frustrated Lewis pair (FLP) catalyst can promote the reductive etherification of aldehydes and ketones. The reaction does not require an exogenous acid catalyst, but the combined action of FLP on H 2 , R‐OH or H 2 O generates the required Brønsted acid in a reversible, “turn on” manner. The method is not only a complementary metal‐free reductive etherification, but also a niche procedure for ethers that would be either synthetically inconvenient or even intractable to access by alternative synthetic protocols.