Palladium‐Catalyzed Oxidative Cascade Carbonylative Spirolactonization of Enallenols | Zendy

Qiu Youai | Zendy; Yang Bin | Zendy; Jiang Tuo | Zendy; Zhu Can | Zendy; Bäckvall JanE. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Palladium‐Catalyzed Oxidative Cascade Carbonylative Spirolactonization of Enallenols

Author(s) -

Qiu Youai,

Yang Bin,

Jiang Tuo,

Zhu Can,

Bäckvall JanE.

Publication year - 2017

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201612384

Subject(s) - carbonylation , palladium , chemistry , catalysis , carbon monoxide , olefin fiber , enantioselective synthesis , oxidative phosphorylation , cascade , monoxide , combinatorial chemistry , cascade reaction , oxidative addition , organic chemistry , biochemistry , chromatography

A highly selective palladium‐catalyzed oxidative carbonylation/carbocyclization/alkoxycarbonylation of enallenols to afford spirolactones bearing an all‐carbon quaternary center was developed. This transformation involves the overall formation of three C−C bonds and one C−O bond through a cascade insertion of carbon monoxide (CO), an olefin, and CO. Preliminary experiments on chiral anion‐induced enantioselective carbonylation/carbocyclization of enallenols afforded spirolactones with moderate enantioselectivity.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research