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An Efficient Iron(III)‐Catalyzed Aerobic Oxidation of Aldehydes in Water for the Green Preparation of Carboxylic Acids
Author(s) -
Yu Han,
Ru Shi,
Dai Guoyong,
Zhai Yongyan,
Lin Hualin,
Han Sheng,
Wei Yongge
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201612225
Subject(s) - catalysis , chemistry , aqueous solution , generality , reuse , green chemistry , organic chemistry , alcohol oxidation , combinatorial chemistry , waste management , reaction mechanism , psychology , engineering , psychotherapist
The first example of a heterogeneous iron(III)‐catalyzed aerobic oxidation of aldehydes in water was developed. This method utilizes 1 atmosphere of oxygen as the sole oxidant, proceeds under extremely mild aqueous conditions, and covers a wide range of various functionalized aldehydes. Chromatography is generally not necessary for product purification. Its operational simplicity, gram‐scale oxidation, and the ability to successively reuse the catalyst, make this new methodology environmentally benign and cost effective. The generality of this methodology gives it the potential to be used on an industrial scale.