Premium
Real‐Time In Vivo Hepatotoxicity Monitoring through Chromophore‐Conjugated Photon‐Upconverting Nanoprobes
Author(s) -
Peng Juanjuan,
Samanta Animesh,
Zeng Xiao,
Han Sanyang,
Wang Lu,
Su Dongdong,
Loong Daniel Teh Boon,
Kang NamYoung,
Park SungJin,
All Angelo Homayoun,
Jiang Wenxuan,
Yuan Lin,
Liu Xiaogang,
Chang YoungTae
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201612020
Subject(s) - in vivo , chromophore , conjugated system , photon upconversion , luminescence , two photon excitation microscopy , chemistry , nanotechnology , photochemistry , materials science , fluorescence , optoelectronics , organic chemistry , polymer , physics , microbiology and biotechnology , biology , quantum mechanics
Drug toxicity is a long‐standing concern of modern medicine. A typical anti‐pain/fever drug paracetamol often causes hepatotoxicity due to peroxynitrite ONOO − . Conventional blood tests fail to offer real‐time unambiguous visualization of such hepatotoxicity in vivo. Here we report a luminescent approach to evaluate acute hepatotoxicity in vivo by chromophore‐conjugated upconversion nanoparticles. Upon injection, these nanoprobes mainly accumulate in the liver and the luminescence of nanoparticles remains suppressed owing to energy transfer to the chromophore. ONOO − can readily bleach the chromophore and thus recover the luminescence, the presence of ONOO − in the liver leads to fast restoring of the near‐infrared emission. Taking advantages of the high tissue‐penetration capability of near‐infrared excitation/emission, these nanoprobes achieve real‐time monitoring of hepatotoxicity in living animals, thereby providing a convenient screening strategy for assessing hepatotoxicity of synthetic drugs.