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Anaerobe‐Inspired Anticancer Nanovesicles
Author(s) -
Qian Chenggen,
Feng Peijian,
Yu Jicheng,
Chen Yulei,
Hu Quanyin,
Sun Wujin,
Xiao Xuanzhong,
Hu Xiuli,
Bellotti Adriano,
Shen QunDong,
Gu Zhen
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201611783
Subject(s) - prodrug , in vivo , in vitro , cancer cell , clostridium , chemistry , apoptosis , microbiology and biotechnology , hypoxia (environmental) , bacteria , biology , biochemistry , oxygen , cancer , genetics , organic chemistry
Anaerobic bacteria, such as Clostridium and Salmonella , can selectively invade and colonize in tumor hypoxic regions (THRs) and deliver therapeutic products to destroy cancer cells. Herein, we present an anaerobe nanovesicle mimic that can not only be activated in THRs but also induce hypoxia in tumors by themselves. Moreover, inspired by the oxygen metabolism of anaerobes, we construct a light‐induced hypoxia‐responsive modality to promote dissociation of vehicles and activation of bioreductive prodrugs simultaneously. In vitro and in vivo experiments indicate that this anaerobe‐inspired nanovesicle can efficiently induce apoptotic cell death and significantly inhibit tumor growth. Our work provides a new strategy for engineering stimuli‐responsive drug delivery systems in a bioinspired and synergistic fashion.