Premium
Ruthenium(II)‐Catalyzed meta C−H Mono‐ and Difluoromethylations by Phosphine/Carboxylate Cooperation
Author(s) -
Ruan Zhixiong,
Zhang ShouKun,
Zhu Cuiju,
Ruth Paul Niklas,
Stalke Dietmar,
Ackermann Lutz
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201611595
Subject(s) - phosphine , carboxylate , ruthenium , catalysis , chemistry , cleavage (geology) , substrate (aquarium) , surface modification , scope (computer science) , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , materials science , computer science , oceanography , fracture (geology) , composite material , programming language , geology
Ruthenium(II)‐catalyzed meta ‐selective C−H (di)fluoromethylation was accomplished by phosphine and carboxylate cooperation. The remote C−H functionalization was characterized by ample substrate scope, thereby setting the stage for meta ‐(di)fluoromethylation through facile C−H cleavage.