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Automated Synthesis of Well‐Defined Polymers and Biohybrids by Atom Transfer Radical Polymerization Using a DNA Synthesizer
Author(s) -
Pan Xiangcheng,
Lathwal Sushil,
Mack Stephanie,
Yan Jiajun,
Das Subha R.,
Matyjaszewski Krzysztof
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201611567
Subject(s) - atom transfer radical polymerization , copolymer , monomer , polymer , methacrylate , acrylate , polymerization , reversible addition−fragmentation chain transfer polymerization , polymer chemistry , radical polymerization , chain transfer , chemistry , materials science , living free radical polymerization , organic chemistry
A DNA synthesizer was successfully employed for preparation of well‐defined polymers by atom transfer radical polymerization (ATRP), in a technique termed AutoATRP. This method provides well‐defined homopolymers, diblock copolymers, and biohybrids under automated photomediated ATRP conditions. PhotoATRP was selected over other ATRP methods because of mild reaction conditions, ambient temperature, tolerance to oxygen, and no need to introduce reducing agents or radical initiators. Both acrylate and methacrylate monomers were successfully polymerized with excellent control in the DNA synthesizer. Diblock copolymers were synthesized with different targeted degrees of polymerization and with high retention of chain‐end functionality. Both hydrophobic and hydrophilic monomers were grafted from DNA. The DNA‐polymer hybrids were characterized by SEC and DLS. The AutoATRP method provides an efficient route to prepare a range of different polymeric materials, especially polymer‐biohybrids.