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Hydrodehalogenation of Haloarenes by a Sodium Hydride–Iodide Composite
Author(s) -
Ong Derek Yiren,
Tejo Ciputra,
Xu Kai,
Hirao Hajime,
Chiba Shunsuke
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201611495
Subject(s) - iodide , chemistry , sodium iodide , sodium hydride , hydride , nucleophilic substitution , lithium (medication) , nucleophile , sodium , iodine , nucleophilic aromatic substitution , inorganic chemistry , medicinal chemistry , organic chemistry , catalysis , metal , medicine , endocrinology
A simple protocol for hydrodebromination and ‐deiodination of halo(hetero)arenes was enabled by sodium hydride (NaH) in the presence of lithium iodide (LiI). Mechanistic studies showed that an unusual concerted nucleophilic aromatic substitution operates in the present process.