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Iridium‐Catalyzed Intramolecular Asymmetric Allylic Dearomatization Reaction of Benzoxazoles, Benzothiazoles, and Benzimidazoles
Author(s) -
Yang ZePeng,
Zheng Chao,
Huang Lin,
Qian Chao,
You ShuLi
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201611056
Subject(s) - allylic rearrangement , intramolecular force , iridium , catalysis , chemistry , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry
An iridium‐catalyzed intramolecular asymmetric allylic dearomatization reaction of benzoxazoles, benzothiazoles, and benzimidazoles was developed. The reaction was found to be compatible with a wide range of five‐membered‐ring electron‐deficient heteroaromatic compounds and furnished the corresponding dearomatized heterocycles in high yield with excellent enantioselectivity.