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Buttressing Salicylaldehydes: A Multipurpose Directing Group for C(sp 3 )−H Bond Activation
Author(s) -
Yada Akira,
Liao Wenqing,
Sato Yuta,
Murakami Masahiro
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201610666
Subject(s) - salicylaldehyde , palladium , chemistry , group (periodic table) , catalysis , primary (astronomy) , medicinal chemistry , functional group , stereochemistry , combinatorial chemistry , organic chemistry , schiff base , physics , polymer , astronomy
A palladium‐catalyzed reaction of primary amines with iodoarenes produces γ‐arylated primary amines. A bulky salicylaldehyde, which is marked as easily available, installable, removable, and recoverable, plays a key role in directing palladium to site‐selectively activate the C−H bond located γ to the amino group.
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