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Ligand‐Enabled β‐C–H Arylation of α‐Amino Acids Without Installing Exogenous Directing Groups
Author(s) -
Chen Gang,
Zhuang Zhe,
Li GenCheng,
SaintDenis Tyler G.,
Hsiao Yi,
Joe Candice L.,
Yu JinQuan
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201610580
Subject(s) - chemistry , pyridine , amino acid , ligand (biochemistry) , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , receptor
Herein we report acid‐directed β‐C(sp 3 )‐H arylation of α‐amino acids enabled by pyridine‐type ligands. This reaction does not require the installation of an exogenous directing group, is scalable, and enables the preparation of Fmoc‐protected unnatural amino acids in three steps. The pyridine‐type ligands are crucial for the development of this new C(sp 3 )‐H arylation.