Selective Cascade Reaction of Bisallenes via Palladium‐Catalyzed Aerobic Oxidative Carbocyclization–Borylation and Aldehyde Trapping | Zendy

Naidu Veluru Ramesh | Zendy; Posevins Daniels | Zendy; Volla Chandra M. R. | Zendy; Bäckvall JanE. | Zendy

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Selective Cascade Reaction of Bisallenes via Palladium‐Catalyzed Aerobic Oxidative Carbocyclization–Borylation and Aldehyde Trapping

Author(s) -

Naidu Veluru Ramesh,

Posevins Daniels,

Volla Chandra M. R.,

Bäckvall JanE.

Publication year - 2017

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201610524

Subject(s) - borylation , aldehyde , chemistry , palladium , cascade reaction , regioselectivity , catalysis , trapping , stereoselectivity , cascade , oxidative phosphorylation , combinatorial chemistry , photochemistry , organic chemistry , ecology , biochemistry , alkyl , chromatography , aryl , biology

A cascade reaction, consisting of a palladium‐catalyzed regioselective aerobic oxidative carbocyclization–borylation of bisallenes and a final aldehyde trapping, afforded triene alcohols with high diastereoselectivity. The cascade reaction occurs under mild reaction conditions and proceeds via an allylboron intermediate that is trapped by the aldehyde in a stereoselective manner.

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