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Rhodium‐Catalyzed Asymmetric Synthesis of β‐Branched Amides
Author(s) -
Wu Zhao,
Laffoon Joshua D.,
Nguyen Trang T.,
McAlpin Jacob D.,
Hull Kami L.
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201610500
Subject(s) - enamine , enantioselective synthesis , isomerization , chemistry , rhodium , catalysis , combinatorial chemistry , organic chemistry , organocatalysis
A general asymmetric route for the one‐step synthesis of chiral β‐branched amides is reported through the highly enantioselective isomerization of allylamines, followed by enamine exchange, and subsequent oxidation. The enamine exchange allows for a rapid and modular synthesis of various amides, including challenging β‐diaryl and β‐cyclic.