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Gold‐Catalyzed Direct Oxidative Arylation with Boron Coupling Partners
Author(s) -
Hofer Manuel,
Genoux Alexandre,
Kumar Roopender,
Nevado Cristina
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201610457
Subject(s) - catalysis , chemistry , aryl , boron , ligand (biochemistry) , combinatorial chemistry , oxidative coupling of methane , oxidative phosphorylation , oxidative addition , base (topology) , coupling reaction , coupling (piping) , photochemistry , organic chemistry , materials science , receptor , mathematical analysis , biochemistry , alkyl , mathematics , metallurgy
An efficient synthesis of biaryls through a gold‐catalyzed oxidative cross‐coupling of arenes with strong electron‐deprived aryl boronates is presented herein. Regio‐ and chemocontrol are achieved by the selective activation of these coupling partners by gold at different oxidation states. Under reaction conditions devoid of basic additives or directing groups, the role of acetato ligand as an internal base has been revealed as a key parameter for expanding the reaction scope in these transformations.