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A Robust and Broadly Applicable Cobalt‐Catalyzed Cross‐Coupling of Functionalized Bench‐Stable Organozinc Pivalates with Unsaturated Halides
Author(s) -
Hammann Jeffrey M.,
Lutter Ferdinand H.,
Haas Diana,
Knochel Paul
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201610324
Subject(s) - aryl , halide , catalysis , chemistry , zinc , coupling (piping) , cobalt , combinatorial chemistry , coupling reaction , organic chemistry , medicinal chemistry , materials science , alkyl , metallurgy
We report a robust and broadly applicable CoCl 2 ‐catalyzed cross‐coupling between functionalized aryl and heteroaryl zinc pivalates and various electron‐poor aryl and heteroaryl halides (X=Cl, Br, I). Couplings with (E)‐ or (Z)‐bromo‐ or iodo‐alkenes proceed with retention of configuration. Also, alkynyl bromides react with arylzinc pivalates providing arylated alkynes.