A Robust and Broadly Applicable Cobalt‐Catalyzed Cross‐Coupling of Functionalized Bench‐Stable Organozinc Pivalates with Unsaturated Halides | Zendy

Hammann Jeffrey M. | Zendy; Lutter Ferdinand H. | Zendy; Haas Diana | Zendy; Knochel Paul | Zendy

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A Robust and Broadly Applicable Cobalt‐Catalyzed Cross‐Coupling of Functionalized Bench‐Stable Organozinc Pivalates with Unsaturated Halides

Author(s) -

Hammann Jeffrey M.,

Lutter Ferdinand H.,

Haas Diana,

Knochel Paul

Publication year - 2017

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201610324

Subject(s) - aryl , halide , catalysis , chemistry , zinc , coupling (piping) , cobalt , combinatorial chemistry , coupling reaction , organic chemistry , medicinal chemistry , materials science , alkyl , metallurgy

We report a robust and broadly applicable CoCl 2 ‐catalyzed cross‐coupling between functionalized aryl and heteroaryl zinc pivalates and various electron‐poor aryl and heteroaryl halides (X=Cl, Br, I). Couplings with (E)‐ or (Z)‐bromo‐ or iodo‐alkenes proceed with retention of configuration. Also, alkynyl bromides react with arylzinc pivalates providing arylated alkynes.

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