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Copper‐Catalyzed Enantioselective Alkylation of Enolizable Ketimines with Organomagnesium Reagents
Author(s) -
Ortiz Pablo,
Collados Juan F.,
Jumde Ravindra P.,
Otten Edwin,
Harutyunyan Syuzanna R.
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201609963
Subject(s) - enantioselective synthesis , alkylation , chemistry , reagent , organic chemistry , catalysis , sulfonyl , reactivity (psychology) , phosphine , combinatorial chemistry , cinchona , keto–enol tautomerism , medicine , alkyl , alternative medicine , pathology
Inexpensive and readily available organomagnesium reagents were used for the catalytic enantioselective alkylation of enolizable N ‐sulfonyl ketimines. The low reactivity and competing enolization of the ketimines was overcome by the use of a copper–phosphine chiral catalyst, which also rendered the transformation highly chemoselective and enantioselective for a broad range of ketimine substrates.