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Polymersome Popping by Light‐Induced Osmotic Shock under Temporal, Spatial, and Spectral Control
Author(s) -
Peyret Ariane,
Ibarboure Emmanuel,
Tron Arnaud,
Beauté Louis,
Rust Ruben,
Sandre Olivier,
McClenaghan Nathan D.,
Lecommandoux Sebastien
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201609231
Subject(s) - polymersome , vesicle , biophysics , liposome , osmotic shock , chemistry , electroporation , tonicity , nanotechnology , membrane , materials science , amphiphile , biochemistry , biology , copolymer , organic chemistry , gene , polymer
The light‐triggered, programmable rupture of cell‐sized vesicles is described, with particular emphasis on self‐assembled polymersome capsules. The mechanism involves a hypotonic osmotic imbalance created by the accumulation of photogenerated species inside the lumen, which cannot be compensated owing to the low water permeability of the membrane. This simple and versatile mechanism can be adapted to a wealth of hydrosoluble molecules, which are either able to generate reactive oxygen species or undergo photocleavage. Ultimately, in a multi‐compartmentalized and cell‐like system, the possibility to selectively burst polymersomes with high specificity and temporal precision and to consequently deliver small encapsulated vesicles (both polymersomes and liposomes) is demonstrated.