Mild and Selective Cobalt‐Catalyzed Chemodivergent Transfer Hydrogenation of Nitriles | Zendy

Shao Zhihui | Zendy; Fu Shaomin | Zendy; Wei Mufeng | Zendy; Zhou Shaolin | Zendy; Liu Qiang | Zendy

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Mild and Selective Cobalt‐Catalyzed Chemodivergent Transfer Hydrogenation of Nitriles

Author(s) -

Shao Zhihui,

Fu Shaomin,

Wei Mufeng,

Zhou Shaolin,

Liu Qiang

Publication year - 2016

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201608345

Subject(s) - chemoselectivity , chemistry , transfer hydrogenation , cobalt , selectivity , catalysis , amine gas treating , nitrile , primary (astronomy) , cyanation , combinatorial chemistry , organic chemistry , solvent , ruthenium , physics , astronomy

Herein, we describe a selective cobalt‐catalyzed chemodivergent transfer hydrogenation of nitriles to synthesize primary, secondary, and tertiary amines. The solvent effect plays a key role for the selectivity control. The general applicability of this procedure was highlighted by the synthesis of more than 70 amine products bearing various functional groups in high chemoselectivity. Moreover, this mild system achieved >2000 TONs (turnover numbers) for the transfer hydrogenation of nitriles.

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