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Mild and Selective Cobalt‐Catalyzed Chemodivergent Transfer Hydrogenation of Nitriles
Author(s) -
Shao Zhihui,
Fu Shaomin,
Wei Mufeng,
Zhou Shaolin,
Liu Qiang
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201608345
Subject(s) - chemoselectivity , chemistry , transfer hydrogenation , cobalt , selectivity , catalysis , amine gas treating , nitrile , primary (astronomy) , cyanation , combinatorial chemistry , organic chemistry , solvent , ruthenium , physics , astronomy
Abstract Herein, we describe a selective cobalt‐catalyzed chemodivergent transfer hydrogenation of nitriles to synthesize primary, secondary, and tertiary amines. The solvent effect plays a key role for the selectivity control. The general applicability of this procedure was highlighted by the synthesis of more than 70 amine products bearing various functional groups in high chemoselectivity. Moreover, this mild system achieved >2000 TONs (turnover numbers) for the transfer hydrogenation of nitriles.