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Copper‐Catalyzed Bromination of C(sp 3 )−H Bonds Distal to Functional Groups
Author(s) -
Liu Tao,
Myers Michael C.,
Yu JinQuan
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201608210
Subject(s) - halogenation , chemistry , methylene , catalysis , medicinal chemistry , aryl , reagent , alkyl , copper , organic chemistry
Selective bromination of γ‐methylene C(sp 3 )−H bonds of aliphatic amides and δ‐methylene C(sp 3 )−H bonds of nosyl‐protected alkyl amines are developed using NBS as the brominating reagent and catalytic amount of Cu II /phenanthroline complexes as the catalyst. Aryl and benzylic C−H bonds at other locations remain intact during this directed radical abstraction reaction.