Premium
Copper‐Catalyzed Bromination of C(sp 3 )−H Bonds Distal to Functional Groups
Author(s) -
Liu Tao,
Myers Michael C.,
Yu JinQuan
Publication year - 2017
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201608210
Subject(s) - halogenation , chemistry , methylene , catalysis , medicinal chemistry , aryl , reagent , alkyl , copper , organic chemistry
Selective bromination of γ‐methylene C(sp 3 )−H bonds of aliphatic amides and δ‐methylene C(sp 3 )−H bonds of nosyl‐protected alkyl amines are developed using NBS as the brominating reagent and catalytic amount of Cu II /phenanthroline complexes as the catalyst. Aryl and benzylic C−H bonds at other locations remain intact during this directed radical abstraction reaction.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom