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Access to Acyclic Z ‐Enediynes by Alkyne Trimerization: Cooperative Bimetallic Catalysis Using Air as the Oxidant
Author(s) -
Lee Jin Tu Danence,
Zhao Yu
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201608192
Subject(s) - alkyne , bimetallic strip , enediyne , moiety , chemistry , catalysis , combinatorial chemistry , palladium , yield (engineering) , organic chemistry , materials science , metallurgy
Presented herein is a mild, operationally simple, mix‐and‐go procedure for the synthesis of acyclic trisubstituted Z ‐enediynes, from readily available terminal alkynes, in good yields. This method stems from a serendipitous discovery, and makes use of cooperative palladium/copper bimetallic catalysis and air as an oxidant to effect an intriguing alkyne trimerization to yield the valuable Z ‐enediyne moiety.