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New Design of a Disulfurating Reagent: Facile and Straightforward Pathway to Unsymmetrical Disulfanes by Copper‐Catalyzed Oxidative Cross‐Coupling
Author(s) -
Xiao Xiao,
Feng Minghao,
Jiang Xuefeng
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201608011
Subject(s) - reagent , chemistry , combinatorial chemistry , copper , catalysis , bond cleavage , oxidative coupling of methane , oxidative phosphorylation , sulfur , organic chemistry , biochemistry
A novel reagent, which introduces two sulfur atoms in one step, was designed and used for the construction of diverse disulfanes by copper‐catalyzed oxidative cross‐coupling under mild reaction conditions. By applying this stable and readily prepared reagent, late‐stage modification of pharmaceuticals and natural products can be achieved straightforward. The scaled‐up experiments further indicated the practicality of this protocol. The pH value of the system plays a key role in achieving highly selective cleavage of the C−S bond instead of a S−S bond in the transformation.