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Direct Synthesis of Pyrroles by Dehydrogenative Coupling of Diols and Amines Catalyzed by Cobalt Pincer Complexes
Author(s) -
Daw Prosenjit,
Chakraborty Subrata,
Garg Jai Anand,
BenDavid Yehoshoa,
Milstein David
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201607742
Subject(s) - pincer movement , cobalt , catalysis , chemistry , combinatorial chemistry , metal , coupling (piping) , base (topology) , hydrogen , polymer chemistry , organic chemistry , materials science , mathematical analysis , mathematics , metallurgy
Herein, the first example of base‐metal‐catalyzed dehydrogenative coupling of diols and amines to selectively form functionalized 1,2,5‐substituted pyrroles liberating water and hydrogen gas as the sole by‐products is presented. The reaction is catalyzed by pincer complexes of earth‐abundant cobalt.