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Catalytic Enantioselective Aza‐Piancatelli Rearrangement
Author(s) -
Li Huilin,
Tong Rongbiao,
Sun Jianwei
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201607714
Subject(s) - enantioselective synthesis , cyclopentenone , chemistry , catalysis , combinatorial chemistry , organocatalysis , stereochemistry , organic chemistry
An efficient organocatalytic enantioselective aza‐Piancatelli rearrangement is disclosed. The powerful process provides rapid access to valuable chiral 4‐amino‐2‐cyclopentenone building blocks from readily available 2‐furfurylcarbinols with excellent chemo‐, enantio‐, and diastereoselectivities under mild reaction conditions.