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An Electrophilic Reagent for the Direct Introduction of the SCF 2 PO(OEt) 2 Group to Molecules
Author(s) -
Xiong HengYing,
Bayle Alexandre,
Pannecoucke Xavier,
Besset Tatiana
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201607231
Subject(s) - reagent , electrophile , nucleophile , chemistry , molecule , combinatorial chemistry , group (periodic table) , medicinal chemistry , organic chemistry , catalysis
Abstract An unprecedented electrophilic difluoromethylthiolating reagent (MesNHSCF 2 PO(OEt) 2 ) was designed. Under mild and metal‐free conditions, this new reagent reacted with various nucleophiles, thus offering an efficient and operationally simple tool for the construction of C−SCF 2 PO(OR) 2 , N−SCF 2 PO(OR) 2 , and S−SCF 2 PO(OR) 2 bonds. Finally, thanks to this new methodology, the synthesis of the non‐stereoidal anti‐inflammatory diflumidone was achieved.