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Tandem Difluoroalkylation‐Arylation of Enamides Catalyzed by Nickel
Author(s) -
Gu JiWei,
Min QiaoQiao,
Yu LingChao,
Zhang Xingang
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201606458
Subject(s) - nickel , catalysis , tandem , inert , chemistry , combinatorial chemistry , functional group , compatibility (geochemistry) , substrate (aquarium) , cascade reaction , reaction conditions , organic chemistry , materials science , composite material , geology , polymer , oceanography
A nickel‐catalyzed three‐component reaction for the synthesis of difluoroalkylated compounds through tandem difluoroalkylation‐arylation of enamides has been developed. The reaction tolerates a variety of arylboronic acids and widely available difluoroalkyl bromides, and even the relatively inert substrate chlorodifluoroacetate. The significant advantages of this protocol are the low‐cost nickel catalyst, synthetic convenience, excellent functional‐group compatibility and high reaction efficiency.