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Diastereoselective Synthesis of Cyclopenta[ c ]furans by a Catalytic Multicomponent Reaction
Author(s) -
Pathipati Stalin R.,
van der Werf Angela,
Eriksson Lars,
Selander Nicklas
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201606108
Subject(s) - furan , chemistry , catalysis , indium , combinatorial chemistry , component (thermodynamics) , reaction conditions , organic chemistry , physics , thermodynamics
A diastereoselective three‐component reaction between alkynyl enones, aldehydes and secondary amines is reported. With the aid of a benign indium catalyst, a range of highly substituted cyclopenta[ c ]furan derivatives can be obtained in a single‐step procedure. The formation of the stereodefined heterocyclic motifs takes place via in situ generation of enamines followed by two sequential cyclization steps.