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General, Highly Selective Synthesis of 1,3‐ and 1,4‐Difunctionalized Building Blocks by Regiodivergent Epoxide Opening
Author(s) -
Funken Nico,
Mühlhaus Felix,
Gansäuer Andreas
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201606064
Subject(s) - epoxide , chemistry , branching (polymer chemistry) , combinatorial chemistry , catalysis , natural product , enantioselective synthesis , stereochemistry , organic chemistry
We describe a regiodivergent epoxide opening (REO) featuring a catalyst‐controlled synthesis of enantiomerically and diastereomerically highly enriched or pure syn‐ and anti‐ 1,3‐ and 1,4‐difunctionalized building blocks from a common epoxide precursor. The REO is attractive for natural product synthesis and as a branching reaction for diversity‐oriented synthesis with epoxides.