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The First Synthesis of the Sterically Encumbered Adamantoid Phosphazane P 4 (N t Bu) 6 : Enabled by Mechanochemistry
Author(s) -
Shi Yan X.,
Xu Kai,
Clegg Jack K.,
Ganguly Rakesh,
Hirao Hajime,
Friščić Tomislav,
García Felipe
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201605936
Subject(s) - steric effects , mechanochemistry , chemistry , reactivity (psychology) , molecule , phosphorus , stereochemistry , organic chemistry , medicine , alternative medicine , pathology
All reported attempts to synthesize the tert ‐butyl‐substituted adamantoid phosph(III)azane P 4 (N t Bu) 6 have failed, leading to the classification of this molecule as inaccessible and a literature example of steric control in chemistry of phosphorus‐nitrogen compounds. We now demonstrate that this structure is readily accessible by a solvent‐free mechanochemical milling approach, highlighting the importance of mechanochemical reaction environments in evaluating chemical reactivity.