Premium
Selective Synthesis of Six Products from a Single Indolyl α‐Diazocarbonyl Precursor
Author(s) -
James Michael J.,
O'Brien Peter,
Taylor Richard J. K.,
Unsworth William P.
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201605337
Subject(s) - diazo , catalysis , chemistry , decomposition , combinatorial chemistry , organic chemistry
Indolyl α‐diazocarbonyls can be selectively cyclized to give six distinct products through the careful choice of catalyst and reaction conditions. A range of catalysts were used, including complexes of Rh II , Pd II , and Cu II , as well as SiO 2 , to promote diazo decomposition and subsequent cyclization/rearrangement through a range of mechanistic pathways.