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Nickel‐Catalyzed Reductive Amidation of Unactivated Alkyl Bromides
Author(s) -
Serrano Eloisa,
Martin Ruben
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201605162
Subject(s) - chemoselectivity , alkyl , catalysis , chemistry , reagent , nickel , primary (astronomy) , stoichiometry , combinatorial chemistry , organic chemistry , physics , astronomy
A user‐friendly, nickel‐catalyzed reductive amidation of unactivated primary, secondary, and tertiary alkyl bromides with isocyanates is described. This catalytic strategy offers an efficient synthesis of a wide range of aliphatic amides under mild conditions and with an excellent chemoselectivity profile while avoiding the use of stoichiometric and sensitive organometallic reagents.