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Selective Palladium‐Catalyzed Aminocarbonylation of Olefins to Branched Amides
Author(s) -
Liu Jie,
Li Haoquan,
Spannenberg Anke,
Franke Robert,
Jackstell Ralf,
Beller Matthias
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201605104
Subject(s) - chemistry , catalysis , palladium , halide , pyrrole , ligand (biochemistry) , organic chemistry , combinatorial chemistry , medicinal chemistry , biochemistry , receptor
A general and efficient protocol for iso‐selective aminocarbonylation of olefins with aliphatic amines has been developed for the first time. Key to the success for this process is the use of a specific 2‐phosphino‐substituted pyrrole ligand in the presence of PdX 2 (X=halide) as a pre‐catalyst. Bulk industrial and functionalized olefins react with various aliphatic amines, including amino‐acid derivatives, to give the corresponding branched amides generally in good yields (up to 99 %) and regioselectivities ( b / l up to 99:1).