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Metal‐Free Cross‐Coupling of Arylboronic Acids and Derivatives with DAST‐Type Reagents for Direct Access to Diverse Aromatic Sulfinamides and Sulfonamides
Author(s) -
Wang Qiang,
Tang XiangYing,
Shi Min
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201605066
Subject(s) - reagent , chemistry , combinatorial chemistry , metal , coupling reaction , coupling (piping) , reaction conditions , organic chemistry , catalysis , materials science , metallurgy
We have developed a simple and convenient method for the cross‐coupling of arylboronic acids and their derivatives with DAST‐type reagents under mild and metal‐free conditions to directly afford sulfinamides in moderate to good yields. Moreover, sulfonamides were obtained after a simple oxidation reaction. The reaction mechanism was investigated by 18 O‐labeling experiments, and the synthetic utility was demonstrated by the sulfoxidation of natural products.