Construction of Chiral Tri‐ and Tetra‐Arylmethanes Bearing Quaternary Carbon Centers: Copper‐Catalyzed Enantioselective Propargylation of Indoles with Propargylic Esters | Zendy

Tsuchida Kouhei | Zendy; Senda Yasushi | Zendy; Nakajima Kazunari | Zendy; Nishibayashi Yoshiaki | Zendy

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Construction of Chiral Tri‐ and Tetra‐Arylmethanes Bearing Quaternary Carbon Centers: Copper‐Catalyzed Enantioselective Propargylation of Indoles with Propargylic Esters

Author(s) -

Tsuchida Kouhei,

Senda Yasushi,

Nakajima Kazunari,

Nishibayashi Yoshiaki

Publication year - 2016

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201604182

Subject(s) - enantioselective synthesis , chemistry , copper , cycloaddition , catalysis , quaternary carbon , combinatorial chemistry , organic chemistry , carbon fibers , materials science , composite number , composite material

Copper‐catalyzed enantioselective propargylation of indoles with propargylic esters and sequential Huisgen cycloaddition with azides lead to the construction of chiral triarylmethanes, bearing a quaternary carbon center, with high to excellent enantioselectivities. The result described herein can be used in the enantioselective preparation of a tetraarylmethane.

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