Premium
Synthesis of α‐Fluoroketones by Insertion of HF into a Gold Carbene
Author(s) -
Zeng Xiaojun,
Liu Shiwen,
Shi Zhenyu,
Liu Guangchang,
Xu Bo
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201603914
Subject(s) - carbene , alkyne , cationic polymerization , chemistry , hydrogen fluoride , fluoride , functional group , combinatorial chemistry , insertion reaction , gold alloys , catalysis , photochemistry , polymer chemistry , organic chemistry , inorganic chemistry , polymer , alloy
Reported is an efficient synthesis of α‐fluoroketones by insertion of hydrogen fluoride (HF) into the gold carbene intermediate, generated from a cationic gold catalyzed addition of N ‐oxides to alkynes. This method results in excellent chemical yields for a wide range of alkyne substrates and demonstrates good functional‐group tolerance.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom