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Synthesis of α‐Fluoroketones by Insertion of HF into a Gold Carbene
Author(s) -
Zeng Xiaojun,
Liu Shiwen,
Shi Zhenyu,
Liu Guangchang,
Xu Bo
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201603914
Subject(s) - carbene , alkyne , cationic polymerization , chemistry , hydrogen fluoride , fluoride , functional group , combinatorial chemistry , insertion reaction , gold alloys , catalysis , photochemistry , polymer chemistry , organic chemistry , inorganic chemistry , polymer , alloy
Abstract Reported is an efficient synthesis of α‐fluoroketones by insertion of hydrogen fluoride (HF) into the gold carbene intermediate, generated from a cationic gold catalyzed addition of N ‐oxides to alkynes. This method results in excellent chemical yields for a wide range of alkyne substrates and demonstrates good functional‐group tolerance.