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Metal‐Free [2+2+2] Cycloaddition of Ynamides and Nitriles: Mild and Regioselective Synthesis of Fully Substituted Pyridines
Author(s) -
Wang Yong,
Song LiJuan,
Zhang Xinhao,
Sun Jianwei
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201603889
Subject(s) - regioselectivity , cycloaddition , chemoselectivity , chemistry , combinatorial chemistry , catalysis , brønsted–lowry acid–base theory , intermolecular force , organic chemistry , molecule
A metal‐free trimolecular [2+2+2] cycloaddition of internal ynamides and nitriles for de novo synthesis of fully substituted pyridines is disclosed. With the versatile Brønsted acid catalyst HNTf 2 , the mild intermolecular cyclotrimerization process proceeds with complementary chemoselectivity and excellent regioselectivity.