Esters, Including Triglycerides, and Hydrogen as Feedstocks for the Ruthenium‐Catalyzed Direct N‐Alkylation of Amines | Zendy

Adam Rosa | Zendy; CabreroAntonino Jose R. | Zendy; Junge Kathrin | Zendy; Jackstell Ralf | Zendy; Beller Matthias | Zendy

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Esters, Including Triglycerides, and Hydrogen as Feedstocks for the Ruthenium‐Catalyzed Direct N‐Alkylation of Amines

Author(s) -

Adam Rosa,

CabreroAntonino Jose R.,

Junge Kathrin,

Jackstell Ralf,

Beller Matthias

Publication year - 2016

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201603681

Subject(s) - alkylation , chemistry , ruthenium , triphos , organic chemistry , hydrogen , catalysis , primary (astronomy) , combinatorial chemistry , physics , astronomy

Triglycerides are used for the direct N‐alkylation of amines with molecular hydrogen for the first time. A broad range of interesting and industrially relevant secondary and tertiary amines are obtained in the presence of an in situ formed Ru/Triphos complex. Notably, plant oil can be efficiently applied in this single‐step process. Moreover, a variety of other methyl esters can be used as N‐alkylation agents in the presence of hydrogen for the synthesis of more advanced building blocks.

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