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Esters, Including Triglycerides, and Hydrogen as Feedstocks for the Ruthenium‐Catalyzed Direct N‐Alkylation of Amines
Author(s) -
Adam Rosa,
CabreroAntonino Jose R.,
Junge Kathrin,
Jackstell Ralf,
Beller Matthias
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201603681
Subject(s) - alkylation , chemistry , ruthenium , triphos , organic chemistry , hydrogen , catalysis , primary (astronomy) , combinatorial chemistry , physics , astronomy
Triglycerides are used for the direct N‐alkylation of amines with molecular hydrogen for the first time. A broad range of interesting and industrially relevant secondary and tertiary amines are obtained in the presence of an in situ formed Ru/Triphos complex. Notably, plant oil can be efficiently applied in this single‐step process. Moreover, a variety of other methyl esters can be used as N‐alkylation agents in the presence of hydrogen for the synthesis of more advanced building blocks.