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Rhodium‐Catalyzed Enantioselective Intermolecular Hydroalkoxylation of Allenes and Alkynes with Alcohols: Synthesis of Branched Allylic Ethers
Author(s) -
Liu Zi,
Breit Bernhard
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201603538
Subject(s) - allylic rearrangement , enantioselective synthesis , chemistry , rhodium , catalysis , organic chemistry , yield (engineering) , aryl , medicinal chemistry , materials science , alkyl , metallurgy
Abstract Regio‐ and enantioselective additions of alcohols to either terminal allenes or internal alkynes provides access to allylic ethers by using a Rh I /diphenyl phosphate catalytic system. This method provides an atom‐economic way to obtain chiral aliphatic and aryl allylic ethers in moderate to good yield with good to excellent enantioselectivities.