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Enantioselective Palladium‐Catalyzed Oxidative β,β‐Fluoroarylation of α,β‐Unsaturated Carbonyl Derivatives
Author(s) -
Miró Javier,
del Pozo Carlos,
Toste F. Dean,
Fustero Santos
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201603046
Subject(s) - palladium , catalysis , chemistry , stereoselectivity , enantioselective synthesis , oxidative phosphorylation , combinatorial chemistry , organic chemistry , oxidative addition , oxidative coupling of methane , biochemistry
The site‐selective palladium‐catalyzed three‐component coupling of deactivated alkenes, arylboronic acids, and N ‐fluorobenzenesulfonimide is disclosed herein. The developed methodology establishes a general, modular, and step‐economical approach to the stereoselective β‐fluorination of α,β‐unsaturated systems.