Premium
Enantioselective Palladium‐Catalyzed Oxidative β,β‐Fluoroarylation of α,β‐Unsaturated Carbonyl Derivatives
Author(s) -
Miró Javier,
del Pozo Carlos,
Toste F. Dean,
Fustero Santos
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201603046
Subject(s) - palladium , catalysis , chemistry , stereoselectivity , enantioselective synthesis , oxidative phosphorylation , combinatorial chemistry , organic chemistry , oxidative addition , oxidative coupling of methane , biochemistry
The site‐selective palladium‐catalyzed three‐component coupling of deactivated alkenes, arylboronic acids, and N ‐fluorobenzenesulfonimide is disclosed herein. The developed methodology establishes a general, modular, and step‐economical approach to the stereoselective β‐fluorination of α,β‐unsaturated systems.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom