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Magnetically and Near‐Infrared Light‐Powered Supramolecular Nanotransporters for the Remote Control of Enzymatic Reactions
Author(s) -
Chechetka Svetlana A.,
Yuba Eiji,
Kono Kenji,
Yudasaka Masako,
Bianco Alberto,
Miyako Eijiro
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201602453
Subject(s) - nanorobotics , nanotechnology , supramolecular chemistry , cancer cell , chemistry , nanoparticle , magnetic nanoparticles , infrared , cancer , materials science , biophysics , molecule , biology , organic chemistry , physics , optics , genetics
Cancer is one of the primary causes of death worldwide. A high‐precision analysis of biomolecular behaviors in cancer cells at the single‐cell level and more effective cancer therapies are urgently required. Here, we describe the development of a magnetically‐ and near infrared light‐triggered optical control method, based on nanorobotics, for the analyses of cellular functions. A new type of nanotransporters, composed of magnetic iron nanoparticles, carbon nanohorns, and liposomes, was synthesized for the spatiotemporal control of cellular functions in cells and mice. Our technology will help to create a new state‐of‐the‐art tool for the comprehensive analysis of “real” biological molecular information at the single‐cell level, and it may also help in the development of innovative cancer therapies.