Palladium‐Catalyzed Intramolecular Carbene Insertion into C(sp 3 )−H Bonds | Zendy

Solé Daniel | Zendy; Mariani Francesco | Zendy; Bennasar M.Lluïsa | Zendy; Fernández Israel | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Palladium‐Catalyzed Intramolecular Carbene Insertion into C(sp 3 )−H Bonds

Author(s) -

Solé Daniel,

Mariani Francesco,

Bennasar M.Lluïsa,

Fernández Israel

Publication year - 2016

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201602020

Subject(s) - carbene , palladium , metalation , chemistry , intramolecular force , regioselectivity , catalysis , deprotonation , transmetalation , medicinal chemistry , insertion reaction , functional group , coupling reaction , stereochemistry , organic chemistry , ion , polymer

A palladium‐catalyzed carbene insertion into C(sp 3 )−H bonds leading to pyrrolidines was developed. The coupling reaction can be catalyzed by both Pd 0 and Pd II , is regioselective, and shows a broad functional group tolerance. This reaction is the first example of palladium‐catalyzed C(sp 3 )−C(sp 3 ) bond assembly starting from diazocarbonyl compounds. DFT calculations revealed that this direct C(sp 3 )−H bond functionalization reaction involves an unprecedented concerted metalation–deprotonation step.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research