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Palladium‐Catalyzed Directed para C−H Functionalization of Phenols
Author(s) -
Patra Tuhin,
Bag Sukdev,
Kancherla Rajesh,
Mondal Anirban,
Dey Aniruddha,
Pimparkar Sandeep,
Agasti Soumitra,
Modak Atanu,
Maiti Debabrata
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201601999
Subject(s) - surface modification , phenol , chemistry , palladium , catalysis , biphenyl , combinatorial chemistry , phenols , toluene , organic chemistry
Various practical methods for the selective C−H functionalization of the ortho and recently also of the meta position of an arene have already been developed. Following our recent development of the directing‐group‐assisted para C−H functionalization of toluene derivatives, we herein report the first remote para C−H functionalization of phenol derivatives by using a recyclable silicon‐containing biphenyl‐based template. The effectiveness of this strategy was illustrated with different synthetic elaborations and by the synthesis of various phenol‐based natural products.