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Nickel‐Catalyzed Intramolecular C−O Bond Formation: Synthesis of Cyclic Enol Ethers
Author(s) -
Han SeoJung,
Doi Ryohei,
Stoltz Brian M.
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201601991
Subject(s) - intramolecular force , catalysis , chemistry , enol , nickel , halide , zinc , primary (astronomy) , double bond , organic chemistry , combinatorial chemistry , photochemistry , astronomy , physics
An efficient and exceptionally mild intramolecular nickel‐catalyzed carbon–oxygen bond‐forming reaction between vinyl halides and primary, secondary, and tertiary alcohols has been achieved. Zinc powder was found to be an essential additive for obtaining high catalyst turnover and yields. This operationally simple method allows direct access to cyclic vinyl ethers in high yields in a single step.