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Enantioselective Synthesis of Cyclobutylboronates via a Copper‐Catalyzed Desymmetrization Approach
Author(s) -
GuisánCeinos Manuel,
Parra Alejandro,
MartínHeras Víctor,
Tortosa Mariola
Publication year - 2016
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201601976
Subject(s) - desymmetrization , enantioselective synthesis , cyclobutanes , chemistry , catalysis , copper , combinatorial chemistry , organic chemistry , stereochemistry , cycloaddition
The first catalytic enantioselective synthesis of cyclobutylboronates, by using a chiral copper(I) complex, is reported. A broad variety of cyclobutanes have been prepared with consistently high levels of diastereo‐ and enantiocontrol. Moreover, this method constitutes the first report of an enantioselective desymmetrization of meso‐cyclobutenes to prepare chiral cyclobutanes.